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Grants to USA Entities for Scientific
Research to Improve Biofuels

Biosystems Design to Enable Safe Production of Next-Generation Biofuels, Bioproducts and Biomaterials

Agency Type:


Funding Source:

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U.S. Department of Energy (DOE) - Office of Science (SC) - Biological and Environmental Research (BER)

LOI Date:


Deadline Date:

04/07/22 11:59 PM ET


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Grants to USA and territories entities for scientific research to develop and improve biofuels and other biological materials. Pre-applications are required prior to the submission of full applications. Applicants are advised that required registrations may take several weeks to complete.

The DOE SC program in Biological and Environmental Research (BER) hereby announces its interest in receiving applications for research within the Biological Systems Science Division‘s (BSSD) Genomic Science Program (GSP) mission-space. This FOA solicits applications in the following research areas:

  1. Microbial biosystems design: Interdisciplinary, fundamental systems biology research to advance the development of new genome-wide design and engineering technologies, innovative modeling, and high-throughput testing approaches for a broad range of prokaryotic and eukaryotic microbes relevant to the production of biofuels and bioproducts from biomass, from synthetic polymers, or as a byproduct of photosynthesis.
  2. Plant biosystems design: Integrative, basic research in plant systems biology, genome-scale modeling, design, and engineering to advance towards the development of enhanced bioenergy crops, capable of producing biofuels, bioproducts, biomaterials and/or their precursors while growing in marginal environments.

Applications must include strategies to address biocontainment, minimizing risks of potential release of engineered organisms into the environment or other unintended outcomes.

For additional information, see #page=8.

GrantWatch ID#:

GrantWatch ID#: 200655

Estimated Total Program Funding:


Number of Grants:

Approximately six to 12 awards are expected.

Estimated Size of Grant:

Award Ceiling: $5,000,000 per year
Award Floor: $1,000,000 per year

Term of Contract:

DOE anticipates making awards with a project period of five years.

Continuation funding (funding for the second and subsequent budget periods) is contingent on: (1) availability of funds appropriated by Congress and future year budget authority; (2) progress towards meeting the objectives of the approved application; (3) submission of required reports; and (4) compliance with the terms and conditions of the award.

Additional Eligibility Criteria:

All types of domestic applicants are eligible to apply, except nonprofit organizations described in section 501(c)(4) of the Internal Revenue Code of 1986 that engaged in lobbying activities after December 31, 1995.

Federally affiliated entities must adhere to the eligibility standards listed here:

Individuals with the skills, knowledge, and resources necessary to carry out the proposed research as a Principal Investigator (PI) are invited to work with their organizations to develop an application. Individuals from underrepresented groups as well as individuals with disabilities are always encouraged to apply.

Multi-institutional teams must submit one application from a designated lead institution with all other team members proposed as subrecipients.

DOE/National Nuclear Security Administration (NNSA) National Laboratories, other Federal agencies, and another Federal agency’s FFRDCs, if participating in a team led by another institution, must be proposed as subrecipients.

Collaborative applications (in which each team member submits its own application with a common research narrative) will not be accepted under this FOA.

The following areas are not within the scope of this FOA: Starch-, waste-, natural gas- or coal-derived biofuels, bioproducts or biomaterials; microbial fuel cells; electrosynthesis; wastewater; municipal solid waste; bioremediation; bioprospecting; biomimetics/biohybrids; food crops; production of ethanol, biogas, hydrogen, pharmaceuticals, nutraceuticals, cosmetics, or food products. Projects focused on titer/yield improvement or scale-up production in established microbial systems are not within the scope of BSSD. Research that would result in only incremental knowledge or technological advances, or applications focused solely on technology development will not be considered.

Pre-Application Information:

- Submission Deadline for Pre-Applications: January 26, 2022 at 5:00 PM Eastern Time. A Pre-Application is required.
- Pre-Application Response Date: February 9, 2022 at 5:00 PM Eastern Time
- Submission Deadline for Applications: April 7, 2022 at 11:59 PM Eastern Time
- It is anticipated that the award selection will be completed by July 2022. It is expected that awards will be made in Fiscal Year 2022.

The Department of Energy (DOE) Office of Science (SC) encourages you to register in all systems as soon as possible. You are also encouraged to submit letters of intent (LOIs), pre-applications, and applications well before the deadline.

Organizations must have a Data Universal Numbering System (DUNS) Number, active System for Award Management (SAM) registration, and account to apply for grants.

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For a list of relevant application documents, go to the Package tab (press Preview) on the link above.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit pre-application online:

Technical/Scientific Program Contact:
Dr. Pablo Rabinowicz Customer Support:
800-518-4726 (toll-free)

PAMS Customer Support:
855-818-1846 (toll-free)

CFDA Number:


Funding or Pin Number:


URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Array ( [0] => American Samoa (USA); [1] => Guam (USA); [2] => Puerto Rico (USA); [3] => Virgin Islands (USA); [4] => Northern Mariana Islands (USA); )

USA Territories: American Samoa (USA);   Guam (USA);   Puerto Rico (USA);   Virgin Islands (USA);   Northern Mariana Islands (USA);

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