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Grants to USA Nonprofits and Tribal Governments for Projects to
Enhance the Quality of Life for Children with Special Medical Needs

Enhancing Systems of Care for Children with Medical Complexity (Demonstration Projects)

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Funding Source:

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U.S. Department of Health and Human Services (DHHS) - Health Resources and Services Administration (HRSA) - Maternal and Child Health Bureau, Division of Services for Children with Special Health Needs

Conf. Date:


Deadline Date:

03/07/22 11:59 PM ET


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Grants to USA nonprofit organizations, faith-based organizations, and tribal governments for projects that enhance the quality of life for children with special medical needs. Applicants are advised that required registrations may take up to several weeks to complete. Eligible projects are those with an emphasis on unserved and underserved populations.

The purpose of this program is to optimize the health, quality of life, and well-being of children with medical complexity (CMC) and their families.

The goal of the Enhancing Systems of Care for Children with Medical Complexity program is to improve the quality, coordination, and experience of care and services for children with medical complexity and their families/caregivers. For purposes of this program, CMC, a subset of children with special health care needs, are characterized as children having family-identified service needs, severe chronic clinical conditions, functional limitations, and high utilization of health resources.

HRSA-22-098 (Demonstration projects): Up to five demonstration projects will be funded to implement and evaluate evidence-informed models of care designed to optimize the child’s health, general functioning/quality of life, and family well-being. The models of care should be accessible, continuous, comprehensive, coordinated, compassionate, culturally effective, and patient/ family-centered. Proposed models are expected to:

  • Expand equitable access to quality patient/family-centered services, with an emphasis on CMC from unserved or underserved populations or communities; 
  • Optimize use of innovative technologies, such as telehealth, to facilitate comprehensive, coordinated, and continuous services across the care continuum; and
  • Apply an equity-informed approach to health care delivery for CMC and equip their families with the knowledge of and/or access to medical, social, financial, or community resources they need for their children to thrive.

For further information, see Pae 8 of the RFP document in Supporting Documents, below.

GrantWatch ID#:

GrantWatch ID#: 200256

Estimated Total Program Funding:


Number of Grants:


Estimated Size of Grant:

Award Ceiling: $400,000
Award Floor: $0

Term of Contract:

August 1, 2022 through July 31, 2027 (5 years)


Additional Eligibility Criteria:

Eligible applicants for both HRSA-22-098 (Demonstration Projects) and HRSA-22-088 (Coordinating Center) include any domestic public or private entity, including an Indian tribe or tribal organization (as those terms are defined at 25 U.S.C. § 450b). See 42 CFR § 51a.3(a). Domestic faith-based and community-based organizations are eligible to apply.

For information on funding restrictions, see Page 29 of the RFP document in Supporting Documents, below.

Pre-proposal Conference:

HRSA has scheduled the following technical assistance:

Day and Date: Monday, December 20, 2021
Time: 3 – 4:30 p.m. ET
Call-In Number: 1-833-568-8864
Meeting ID: 160 565 5601
Participant Code: 12203071
Meeting ID: 160 565 5601
Passcode: 17uCY6qi

HRSA will record the webinar and make it available at:

Pre-Application Information:

The due date for applications under this NOFO is March 7, 2022 at 11:59 p.m. ET.

HRSA suggests submitting applications to at least 3 calendar days before the deadline to allow for any unforeseen circumstances.

HRSA requires you to apply electronically. HRSA encourages you to apply through using the SF-424 workspace application package associated with this notice of funding opportunity (NOFO).

Currently, the registration process requires information in three separate systems:
• Dun and Bradstreet (
• System for Award Management (SAM) ( | Knowledge Base)
• (

View this opportunity on

For a list of relevant application documents, see the Package tab (click Preview) on the link listed above.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

You may request additional information and/or technical assistance regarding business, administrative, or fiscal issues related to this NOFO by contacting:

Tya Renwick
Grants Management Specialist
Division of Grants Management Operations, OFAM
Health Resources and Services Administration
5600 Fishers Lane, Mailstop 10SWH03
Rockville, MD 20857
Telephone: (301) 594-0227

You may request additional information regarding the overall program issues and/or technical assistance related to this NOFO by contacting:

Anna Maria Padlan
Public Health Analyst, Division of Services for Children with Special Health Needs
Attn: Enhancing Systems of Care for Children with Medical Complexity
Maternal and Child Health Bureau
Health Resources and Services Administration
5600 Fishers Lane, Room 18W-10D
Rockville, MD 20857
Telephone: (301) 443-1737
Email: support: Contact Center
Telephone: 1-800-518-4726 (International callers dial 606-545-5035)

or assistance with submitting in the EHBs, contact the HRSA
Contact Center, Monday–Friday, 7 a.m. to 8 p.m. ET, excluding federal holidays at:
HRSA Contact Center
Telephone: (877) 464-4772 / (877) Go4-HRSA
TTY: (877) 897-9910

CFDA Number:


Funding or Pin Number:


URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Array ( )

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